John Wayne as Breck Coleman

Marguerite Churchill as Ruth Cameron

El Brendel as Gus

Tully Marshall as Zeke

Tyrone Power Sr. as Red Flack

David Rollins as Dave Cameron

Frederick Burton as Pa Bascom

Ian Keith as Bill Thorpe

Charles Stevens as López

Louise Carver as Gus' Mother-in-law

Victor Adamson as Wagon Train Man (uncredited)

Phyllis Bainbridge as Pioneer (uncredited)

Chief John Big Tree as Indian (uncredited)

Ward Bond as Sid Bascom (uncredited)

Nora Bush as Pioneer (uncredited)

Martin Cichy as Pioneer (uncredited)

Don Coleman as Wrangler (uncredited)

Nancy Crowley as Pioneer Child (uncredited)

Curley Dresden as Pioneer (uncredited)

Adabelle Driver as Pioneer (uncredited)

Emslie Emerson as Sairey (uncredited)

Alphonse Ethier as Marshal (uncredited)

Theresa Garon as Pioneer (uncredited)

William Gillis as Pioneer (uncredited)

Dannie Mac Grant as Pioneer Boy (uncredited)

Virginia Griffith as Pioneer (uncredited)

Marcia Harris as Mrs. Riggs (uncredited)

Marilyn Harris as Pioneer Girl (uncredited)

Al Haskell as Pioneer (uncredited)

DeWitt Jennings as Boat Captain Hollister (uncredited)

Jack Kenny as Pioneer (uncredited)

Bert Keys as Pioneer (uncredited)

John Lawrence Kneedy as Wagon Driver (uncredited)

Ann Kunde as Pioneer (uncredited)

Marjorie Leet as Mildred Riggs (uncredited)

Marion Lessing as Pioneer Girl (uncredited)

Frances Martinson as Pioneer (uncredited)

Frank McGrath as Pioneer (uncredited)

William V. Mong as Wellmore (uncredited)

Pete Morrison as Wrangler (uncredited)

Beth Nagel as Pioneer (uncredited)

Dodo Newton as Abigail Vance (uncredited)

Artie Ortego as Pioneer (uncredited)

Jack Padjan as Pioneer (uncredited)

Helen Parrish as Honey Girl Cameron (uncredited)

Robert Parrish as Pioneer Boy (uncredited)

Harvey Parry as Pioneer (uncredited)

Jack Peabody as Bill Gillis (uncredited)

Russ Powell as Windy Bill (uncredited)

Frank Rainboth as Ohio Man (uncredited)

Apache Bill Russell as Indian Scout (uncredited)

Lucile Sewall as Pioneer (uncredited)

Andy Shuford as Ohio Man's Son (uncredited)

Tom Smith as Pioneer (uncredited)

Jean Stoddard as Pioneer (uncredited)

Gertrude Van Lent as Sister from Missouri (uncredited)

Lucille Van Lent as Sister from Missouri (uncredited)