Richard Burton as Alexander

Fredric March as Philip of Macedonia

Claire Bloom as Barsine

Danielle Darrieux as Olympias

Barry Jones as Aristotle

Harry Andrews as Darius

Stanley Baker as Attalus

Niall MacGinnis as Parmenio

Peter Cushing as Memmon

Michael Hordern as Demosthenes

Marisa de Leza as Eurydice (as Marisa De Leza)

Gustavo Rojo as Cleitus

Rubén Rojo as Philotas (as Ruben Rojo)

Peter Wyngarde as Pausanias

Helmut Dantine as Nectenabus

William Squire as Aeschenes

Friedrich von Ledebur as Antipater (as Friedrich Ledebur)

Christopher Lee as Nectenabus (voice)

Virgílio Teixeira as Ptolemy

Julio Peña as Arsites

Carlos Baena as Nearchus

Teresa del Río as Roxane (as Teresa Del Rio)

José Nieto as Spithridates (as Jose Nieto)

Larry Taylor as Perdiccas

José Marco as Harpalus (as Jose Marco)

Ricardo Valle as Hephaestion

Carmen Carulla as Stateira

Jesús Luque as Aristander (as Jesus Luque)

Ramsay Ames as Drunken Woman (as Ramsey Ames)

Ellen Rossen as Amytis

Carlos Acevedo as Ochus

Manuel Arbó as (no acreditado)

Mario Barros as (no acreditado)

Enrique Diosdado as (no acreditado)

Sergio Orta as (no acreditado)

Gérard Tichy as (no acreditado)