Harvey Keitel as Izzy Maurer

Mira Sorvino as Celia Burns

Willem Dafoe as Dr. Van Horn

Gina Gershon as Hannah

Mandy Patinkin as Philip Kleinman

Vanessa Redgrave as Catherine Moore

Don Byron as Tyrone Lord

Richard Edson as Dave Reilly

Victor Argo as Pierre

Kevin Corrigan as Man With Gun

Harold Perrineau as Bobby Perez

Peggy Gormley as Dr. Fisher

Sophie Auster as Sonia Kleinman

Greg Johnson as Stanley Mar

David Byrne as "Laughing Man" Escort

Holly Buczek as Dying Girl

Lou Reed as Not Lou Reed

Tom Gilroy as Restaurant Man #1

Paul Lazar as Restaurant Man #2

Michael Cerveris as Restaurant Man #3

Slava Schoot as Russian Thug

Henry Yuk as Chinese Thug

Fred Norris as German Thug

Brian McGuinness as Pursuer #1

Neil Donovan as Pursuer #2

Socorro Santiago as Paramedic #1

O.L. Duke as Paramedic #2