Brett Gelman as Isaac

Judy Greer as Ramona

Michael Cera as Alex

Gillian Jacobs as Tracy

Jeff Garlin as Guy Roach

Kayla Harrity as Susan

Shiri Appleby as Ruthie

Megan Mullally as Simone

Robin McDonald as Client

Nia Long as Cleo

Jon Daly as Toby

Hank Chen as Lee

Rhea Perlman as Esther

Fred Melamed as Howard

Elizabeth De Razzo as Rosa

Blake Anthony Crawford as Henry

Martin Starr as Adam

Hannah Heller as Zelda

Emma Shannon as Shana

Ashley Silverman as Becca

David Paymer as Dr. Gold

Rex Lee as Jazz

Keith L. Williams as Ruben

Conrad Roberts as Gilly

Theodore Mark Martinez as Cousin Kenmore

Juliette Jeffers as Cousin June

Noel Arthur as Cousin Norman

Jodie Turner-Smith as Beverly

Dionne Audain as Paula

Marla Gibbs as Lily

Divé Assad as Background

Rhonda Bankston as Background

Meica Bradshaw as Background

Linda Brent as Background

Constance Brown as Background

Laroy Campbell as Background

Danny Clash as Background

Alfred Gilliam as Background

Felix Fernando as Background

Bianca Fletcher as Background

Kim Ford as Background

Frank Fuentes as Background

Marion Hanania as Background

David-Ivar Herman Düne as Background

Larry Herskovic as Background

Thoai Ho as Background

Bong-o Hwang as Background

Rina Imai as Background

Anthony Isome as Background

Olga Jefferson-Kerr as Background

Cynthia Lempitsky as Background

John Liscano as Background

Sheila M. Lockhart as Background

Mireya Lucio as Background

Demetrius Lykes as Background

Joseph Mangham as Background

Michael Melwani as Background

John Mollenhauer as Background

Matthew Mooney as Background

Abra Moore as Background

Joe Myers as Background

Kim Nguyen as Background

Lamont Patterson as Background

Tabatha Rajendra as Background

Daniel Rosas as Background

Tony Ramos as Background

Brian Savelson as Background

Etsegenet Tadesse as Background

Valerie Valentine as Background

Leon A. Walker as Background

Victoria Ward as Background

Keith Wheeler as Background

Darrin Wilkerson as Background

Kalent Zaiz as Background

Christophe Zajac-Denek as Background

Inger Tudor as African Woman