Clint Eastwood as Blondie

Eli Wallach as Tuco Ramirez

Lee Van Cleef as Sentenza / Angel Eyes

Aldo Giuffrè as Alcoholic Union Captain

Luigi Pistilli as Father Pablo Ramirez

Rada Rassimov as Maria

Enzo Petito as Storekeeper

Claudio Scarchilli as Tuco Henchman

Antonio Casale as Bill Carson / Jackson

Livio Lorenzon as Baker

Sandro Scarchilli as Tuco Henchman

Benito Stefanelli as Member of Angel Eyes' Gang

Angelo Novi as Monk

Antonio Casas as Stevens

Aldo Sambrell as Member of Angel Eyes' Gang

Al Mulock as One-Armed Bounty Hunter

Sergio Mendizábal as Blonde Bounty Hunter

Antonio Molino Rojo as Captain Harper

Lorenzo Robledo as Clem

Mario Brega as Corporal Wallace

Chelo Alonso as Stevens' Wife (uncredited)

Fortunato Arena as 1st Sombrero Onlooker at Tuco's 1st Hanging (uncredited)

Román Ariznavarreta as Bounty Hunter (uncredited)

Silvana Bacci as Mexican Woman with Blondie (uncredited)

Joseph Bradley as Old Soldier (uncredited)

Frank Braña as Bounty Hunter #2 (uncredited)

Amerigo Castrighella as 2nd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)

Saturno Cerra as Bounty Hunter (uncredited)

William Conroy as Confederate Soldier (uncredited)

Axel Darna as Dying Confederate Soldier (uncredited)

Tony Di Mitri as Deputy (uncredited)

Gianni Di Segni as Deputy at 1st Hanging (uncredited)

Alberigo Donadeo as Spectator Before Hanging (uncredited)

Attilio Dottesio as 3rd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)

Luis Fernández de Eribe as Soldier Coat (uncredited)

Veriano Ginesi as Bald Onlooker at Tuco's 1st Hanging (uncredited)

Jesús Guzmán as Pardue the Hotel Owner (uncredited)

Víctor Israel as Sergeant at Confederate Fort (uncredited)

Nazzareno Natale as Mexican Bounty Hunter (uncredited)

Ricardo Palacios as Barista a Socorro (uncredited)

Antonio Palombi as Old Sergeant (uncredited)

Romano Puppo as Member of Angel Eyes' Gang (uncredited)

Antoñito Ruiz as Stevens' Youngest Son (uncredited)

Aysanoa Runachagua as Pistolero Recruited by Tuco in the Cave (uncredited)

Enrique Santiago as Mexican Bounty Hunter (uncredited)

José Terrón as Thomas 'Shorty' Larson (uncredited)

Franco Tocci as Union Soldier with Cigar (uncredited)

Antonio Montoya as Mexican Bounty Hunter (uncredited)