Jericho Rosales as Manny Pacquiao

Bea Alonzo as Jinky / Janet

Bayani Agbayani as Buboy Fernandez

Jay Manalo as Emong "Kidlat" Dionisio

Glaiza de Castro as Cecille

Andrea Del Rosario as Joana Bacosa

Polo Ravales as Bobby Pacquiao

Tirso Cruz III as Tirso Cruz III as Mang Rosalio (Manny's Father)

Jaclyn Jose as Aling Dionesia (Manny's Mother)

Jiro Manio as Young Manny

Zoren Legaspi as Eric Pineda (business associate)

Ricky Davao as Polding Correa

Gloria Sevilla as Nanay Parcon

Dimples Romana as Emong's Wife

Jim Pebanco as Bayani Ocampo

Tony Mabesa as Ruben Novales

Mon Confiado as Rico Antonio

Biboy Ramirez as Eugene Barotag

Richard Quan as Manny's Uncle

Pinky Amador as Jinkee and Janet's mother

Czarina Dela Peña as Isidra

Emil Sandoval as Jinkee and Janet's father

Manny Pacquiao as himself

Freddie Roach as himself

Empress Schuck as Young Isidra

Valerie Concepcion as Nurse