Jack Webb as Sergeant Joe Friday

Ben Alexander as Officer Frank Smith

Richard Boone as Capt .James E. Hamilton

Ann Robinson as Officer Grace Downey

Stacy Harris as Max Edward Troy

Virginia Gregg as Mrs. Ethel Starkie

Vic Perrin as Deputy D.A. Adolph Alexander

Georgia Ellis as Belle Davitt

James Griffith as Jesse Quinn

Dick Cathcart as Roy Cleaver

Malcolm Atterbury as Lee Reinhard

Willard Sage as Chester Davitt

Olan Soule as Ray Pinker

Dennis Weaver as Capt. R.A. Lohrman

Herb Vigran as Mr. Archer

Virginia Christine as Mrs. Caldwell

James Anderson as Fred Kemp

Cliff Arquette as Charley Weaver

Harry Bartell as Lt. Stevens

Bert Holland as Narrator (voice)

Harry Lauter as Officer Greeley

Bert Stevens as DA S. Ernest Roll

Dub Taylor as Miller Starkie

George Sawaya as McQueen

Meg Myles as Singer at Talent Agency (uncredited)