Charlton Heston as Captain William Frank 'Buffalo Bill' Cody

Rhonda Fleming as Evelyn Hastings

Jan Sterling as Denny Russell

Forrest Tucker as James Butler aka Wild Bill Hickok

Porter Hall as Jim Bridger

Henry Brandon as Joe Cooper

Richard Shannon as Red Barrett

Stuart Randall as Pemberton

Lewis Martin as Sgt. Russell

Pat Hogan as Chief Yellow Hand (uncredited)

Michael Moore as Rance Hastings

Frank Wilcox as Mr. Walstron (uncredited)

Art Felix as Townsman (uncredited)

Chet Brandenburg as Townsman (uncredited)

Harry Tenbrook as Townsman (uncredited)

Chick Hannan as Townsman (uncredited)

George Bell as Townsman (uncredited)