Matt Smith as Robert Mapplethorpe

Marianne Rendón as Patti Smith

John Benjamin Hickey as Sam Wagstaff

Brandon Sklenar as Edward Mapplethorpe

McKinley Belcher III as Milton Moore

Mark Moses as Harry Mapplethorpe

Hari Nef as Tinkerbelle

Carolyn McCormick as Joan Mapplethorpe

Brian Stokes Mitchell as Father Stack

Karan Oberoi as Emilio Acquavella

Kerry Butler as Holly Solomon

Tina Benko as Sandy Daley

Rotimi Paul as Ken Moody

Kenya Brome as Second Assistant

Mickey O'Hagan as Tina Summerlin

Karlee Perez as Lisa Lyon

Christina Rouner as Janet Kardin

Thomas Philip O'Neill as David Croland

Jason Lopez as Tom Baril

David J. Cork as The Catch

Anthony Michael López as Jack Fritscher