Steve Carell as Gru (voice)

Pierre Coffin as Kevin / Stuart / Bob / Minions (voice)

Alan Arkin as Wild Knuckles (voice)

Taraji P. Henson as Belle Bottom (voice)

Michelle Yeoh as Master Chow (voice)

Julie Andrews as Gru's Mom (voice)

Russell Brand as Dr. Nefario (voice)

Jean-Claude Van Damme as Jean Clawed (voice)

Dolph Lundgren as Svengeance (voice)

Danny Trejo as Stronghold (voice)

Lucy Lawless as Nun-Chuck (voice)

Jimmy O. Yang as Henchman 1 (voice)

Kevin Michael Richardson as Henchman 2 (voice)

John DiMaggio as Henchman 3 (voice)

RZA as Biker (voice)

Michael Beattie as VNC Announcer / Guru Rick (voice)

Will Arnett as Mr. Perkins (voice)

Steve Coogan as Silas Ramsbottom (voice)

Colette Whitaker as Gru's Teacher (voice)

Raymond S. Persi as Birthday Kid (voice)

Kyle Balda as Additional Voices (voice)

Bob Bergen as Additional Voices (voice)

Beau Billingslea as Additional Voices (voice)

Cathy Cavadini as Additional Voices (voice)

David Chen as Additional Voices (voice)

Will Collyer as Additional Voices (voice)

Meilee Condron as Additional Voices (voice)

Antonio Raul Garcia as Additional Voices (voice)

Debi Derryberry as Additional Voices (voice)

Scarlett Estevez as Additional Voices (voice)

Kellen Goff as Additional Voices (voice)

Jake Green as Additional Voices (voice)

Isa Hall as Additional Voices (voice)

Ramone Hamilton as Additional Voices (voice)

Aaron Hendry as Additional Voices (voice)

Barbara Harris as Additional Voices (voice)

JP Karliak as Additional Voices (voice)

Evan Kishiyama as Additional Voices (voice)

Sam Lavagnino as Additional Voices (voice)

Dawnn Lewis as Additional Voices (voice)

Amari McCoy as Additional Voices (voice)

Levi Nunez as Additional Voices (voice)

Benjamin Plessala as Additional Voices (voice)

Alex Puccinelli as Additional Voices (voice)

David J. Randolph as Additional Voices (voice)

Carla Rempp as Additional Voices (voice)

Nhev Scharrel as Additional Voices (voice)

James Sie as Additional Voices (voice)

Mindy Sterling as Additional Voices (voice)

Fred Tatasciore as Additional Voices (voice)

Regina Taufen as Additional Voices (voice)

Nisa Ward as Additional Voices (voice)

Debra Wilson as Additional Voices (voice)

Nora Wyman as Additional Voices (voice)