Sandra Bullock as Scarlet Overkill (voice)

Jon Hamm as Herb Overkill (voice)

Michael Keaton as Walter Nelson (voice)

Allison Janney as Madge Nelson (voice)

Steve Coogan as Professor Flux / Tower Guard (voice)

Jennifer Saunders as Reine Elizabeth II (voice)

Geoffrey Rush as Narrator (voice)

Steve Carell as Gru (voice)

Pierre Coffin as Kevin / Stuart / Bob / The Minions (voice)

Katy Mixon as Tina (voice)

Michael Beattie as VNC Announcer / Walter Jr. (voice)

Hiroyuki Sanada as Sumo (voice)

Dave Rosenbaum as Fabrice (voice)

Alex Dowding as Royal Advisor (voice)

Paul Thornley as News Reporter (voice)

Kyle Balda as Additional Voices (voice)

Ava Acres as Additional Voices (voice)

Sherry Lynn as Additional Voices (voice)

Mickie McGowan as Additional Voices (voice)

Carlos Alazraqui as Additional Voices (voice)

Lori Alan as Additional Voices (voice)

Daniel Barker as Additional Voices (voice)

Bob Bergen as Additional Voices (voice)

Melanie Bond as Additional Voices (voice)

Jim Cummings as Additional Voices (voice)

John Cygan as Additional Voices (voice)

Brian T. Delaney as Additional Voices (voice)

Bill Farmer as Additional Voices (voice)

Keith Ferguson as Additional Voices (voice)

Jess Harnell as Additional Voices (voice)

Eve Karpf as Additional Voices (voice)

John Kassir as Additional Voices (voice)

Lewis Macleod as Additional Voices (voice)

Danny Mann as Additional Voices (voice)

Mona Marshall as Additional Voices (voice)

Gary Martin as Additional Voices (voice)

Laraine Newman as Additional Voices (voice)

Andy Nyman as Additional Voices (voice)

Alexander Polinsky as Additional Voices (voice)

Jan Rabson as Additional Voices (voice)

Christopher Ragland as Additional Voices (voice)

Mindy Sterling as Additional Voices (voice)

Tara Strong as Additional Voices (voice)

Jim Ward as Additional Voices (voice)

Colette Whitaker as Additional Voices (voice)

James Daniel Wilson as Additional Voices (voice)