Patrick Wilson as Barry Munday

Malcolm McDowell as Mr. Farley

Judy Greer as Ginger Farley

Chloë Sevigny as Jennifer Farley

Missi Pyle as Lida Griggs

Colin Hanks as Heavy Metal Greg

Jean Smart as Carol Munday

Billy Dee Williams as Lonnie Green

Cybill Shepherd as Mrs. Farley

Carmen Electra as Iconic Beauty

Emily Procter as Deborah

Shea Whigham as Donald

Barret Swatek as Lucy

Christopher McDonald as Dr. Preston Edwards

Trieu Tran as Moe

Razaaq Adoti as Spiro

Matt Winston as Kyle Pennington

Kyle Gass as Jerry Sherman

Michael Rivkin as Maury Knox

Kirk Ward as Roadie #1

Joe Nuñez as Roadie #2

Jenica Bergere as Janice the Midwife

Mae Whitman as Candice

Tori White as Barry's Nurse

Marnie Alexenburg as Secretary #1

William Stanford Davis as Greens Keeper

Ed Solomon as Doctor #2

Becca Sweitzer as Waitress

Jillian Schmitz as Strip Club Dancer

Monica Allgeier as Young Girl

Sam Pancake as D.J.

Cole S. McKay as Driver

Diana Terranova as Bennie

Bruna Rubio as Sasha

Cynthia Adkisson as Young Jennifer

Julia Boyd as Makeout Girl

Michael Durrell as Father Walsh

Yvonne Huff Lee as Pediatric Nurse

Marcelo Tubert as Dr. Shriver

Ashley Guerrero as Beautiful Girl

Colin Malone as Bar Emcee

Barry Habib as Doctor

Andrew Magarian as Candice's Father

Eurydice Davis as Tammy

Mark Riccardi as Bouncer

Jeff Sanders as Bouncer #2

Stone Douglass as Child Bodybuilding Pageant Announcer

Jennifer M. Coll as Denise

Chris D'Arienzo as Newton Creech

Youlanda Davis as Office Manager

Geoffrey Gould as Barry

Rebecca Howard as Tracy

Charlotte Roller as Cornelia

Kristina Sefeldt as Ex-girlfriend

Willam Belli as Felicia