Nick Nolte as Amadeus

Matt Dillon as Nick

Emily Mortimer as Sarah

Sophie Lane Nolte as Matilda

Jacqueline Bisset as Vivian

Eric Roberts as Dr. Holst

Greta Scacchi as Abbess

Julian Ovenden as Serge

Jake Weber as Dr. Edwards

Til Schweiger as Waiter London Restaurant

Joplin Sibtain as Mickey

Claire Forlani as Headmistress

Dominic Coleman as Officer Police Station

Emily Cox as Nursing Home Manager

Max Befort as Man at Ticket Counter

Toni Garrn as Nora

Leigh Gill as Vince

Elisabeth Kanettis as Nun

Anna-Lea Mende as Nun in Garden

Alistair Brammer as Waiter in Train Restaurant

J. David Hinze as Priest

Nicholas Reinke as Pyrotechnician

Giampiero Judica as Hotel Receptionist

Jessica McIntyre as Doctor's Receptionist

Michael Klammer as Carabiniere

Tim Wilde as Train Guard

Simone Spinazzè as Capitano

Luca Ribezzo as Police Chief

Nicola Ransom as Secretary

Murali Perumal as Emre

Veronica Ferres as Woman in Orient Express

Noah Petersen as Marius

Ian Thomas McMillan as Tourette's Patient

Valerie Huber as Nurse

Jo Ashe as Hilda

Sylvia Pugliese as Loretta

Lisa Ayimah as Female Police Officer

Penelope Frego as Female Receptionist

Lia Bottazzi as Wrong Leading Girl in Train Station

Sami Nasser as Rick

Sophia Burandt as Matilda's Friend

Suryani Hardt as Smilla

Samuel Finzi as Cameriere

Aida Turturro as Margaret

Peter Schorn as Train Guard at Station

Costa Ronin as Russian Oligarch in Restaurant

Emma Schweiger as South Tyrol Farm Girl

Hilly Martinek as Caregiver

Petra Rohregger as Woman at Platform

Alexa Brunner as Woman at Platform

Richard Arame as Mourner

Michele Ritter as Mourner

Rodney Geitel-Bautista as Mourner

Youssef Rabbaoui as Man at Nursing Home

Christoph Domanski as Bobby

Sascha Strutz as Bobby

Tatjana Zweck as Old Couple in Train

Klaus Burkhardt as Old Couple in Train

May Nivola as Girl in Venice (background actor)