Kenneth Branagh as Franklin Delano Roosevelt

Cynthia Nixon as Eleanor Roosevelt

David Paymer as Louis Howe

Tim Blake Nelson as Tom Loyless

Matt O'Leary as Fred Botts

Matt Malloy as Lionel Purdy

Andy Davoli as Jake Perini

Nelsan Ellis as Roy Collier

Jane Alexander as Sara Delano Roosevelt

Kathy Bates as Helena Mahoney

Melissa Ponzio as Lucy Mercer

Quint Von Canon as Stephen Teller

Mike Pniewski as Hastings

Grayce Spence as League Member

Rand Hopkins as Dr. Lovett

Brian F. Durkin as Elliott Roosevelt

Carrie Adams as Anna - Age 19

Georgia Miles as Anna - Age 12

Devon Gearhart as Elliot - Age 8 and 11

Tripp Hennington as Franklin Junior - Age 9

Sam Frihart as John - Age 7

Matthew Stanton as Scoutmaster

Ron Clinton Smith as Eugene

Lonnie R. Smith Jr. as Stanley

Jill Jane Clements as Waitress

Dave Hager as Pat Doyle

Felicia Day as Eloise Hutchinson

Meggie Geisland as Daisy

E. Roger Mitchell as Pete Collier

Deborah Duke as Aunt Sally

Bob Seel as Cleburne Gregory

Brian Beegle as Benjamin Pendergrast

Steve Coulter as Dr. Bissell

Marianne Fraulo as Missy Lehand

Jody Thompson as Woodhall Busey

Frank Hoyt Taylor as Conductor

Lori Beth Sikes as Mary Beth

Teal Sherer as Chorus Girl #1

Margo G. Dietrich as Chorus Girl #2

Laurel Lawson as Chorus Girl #3

Danny Nelson as Farmer

Sharon Blackwood as Farmer's Wife

Bart Hansard as Stationmaster at Bullochsville

Terry Loughlin as Dr. Peter Hebert

Marc McPherson as Dr. Willis

J.L. Parker as Helena's Driver

Wilbur Fitzgerald as Al Smith

Terrence Gibney as Crony #1

David Silverman as Crony #2

Robert C. Treveiler as Dan Reed

Carl McIntyre as Reporter

Greg Thompson as Photographer

Ron Goss as Convention Announcer