Tom Holland as Peter Parker / Spider-Man

Zendaya as MJ

Benedict Cumberbatch as Doctor Strange

Jacob Batalon as Ned Leeds

Jon Favreau as Happy Hogan

Jamie Foxx as Max Dillon / Electro

Willem Dafoe as Norman Osborn / Green Goblin

Alfred Molina as Dr. Otto Octavius / Doc Ock

Benedict Wong as Wong

Tony Revolori as Flash Thompson

Marisa Tomei as May Parker

Andrew Garfield as Peter Parker / Spider-Man

Tobey Maguire as Peter Parker / Spider-Man

Angourie Rice as Betty Brant

Arian Moayed as Agent Cleary

Paula Newsome as MIT Assistant Vice Chancellor

Hannibal Buress as Coach Wilson

Martin Starr as Mr. Harrington

JB Smoove as Mr. Dell

J.K. Simmons as J. Jonah Jameson

Rhys Ifans as Dr. Curt Connors / The Lizard

Charlie Cox as Matt Murdock

Thomas Haden Church as Flint Marko / Sandman

Haroon Khan as Apprentice

Emily Fong as Apprentice

Mary Rivera as Ned's Lola

Rudy Eisenzopf as Arena Bystander

Kathleen Cardoso as Arena Bystander

Jonathan Sam as Arena Bystander

Andrew Dunlap as Dad in Car

Zany Dunlap as Mom in Car

B. Clutch Dunlap as Kid in Car

Minnah Dunlap as Kid in Car

Ben VanderMey as Man in Car

Gary Weeks as Agent Foster

Gregory Konow as Donut Shop Boss

Carol Anne Dines as Donut Shop Waitress

Anisa Nyell Johnson as School Security Guard

Willie D. Burton as May's Neighbor

Mallory Hoff as Reporter

Greg Clarkson as Reporter

Regina Ting Chen as Reporter

Robert Mitchel Owenby as Daily Bugle Lackey

Glenn Keogh as British Reporter

Paris Benjamin as British Anchor

Jwaundace Candece as Damage Control Agent

Taylor St. Clair as Protestor

Rolando Fernandez as Crowd Member

Gabriella Cila as Crowd Member

Darnell Appling as Crowd Member

Edward Force as Donut Shop Patron

Michael Le as Guy with Phone

Dean Meminger as NY1 Reporter

Frederick A. Brown as Fred the Janitor

Cristo Fernández as Bartender

Clay Savage as Suit Voice (voice)

Tom Hardy as Eddie Brock / Venom (uncredited)

Jay Karales as Bodega Customer (uncredited)

John Barnes as School Protester (uncredited)

Harry Holland as Shaker Kid (uncredited)

John M. Maiers as Paparazzi (uncredited)

Cole Failing as Midtown High Student (uncredited)

Robert Tinsley as Protestor / Pedestrian (uncredited)