Sean Penn as Paul Rivers

Naomi Watts as Cristina Peck

Benicio del Toro as Jack Jordan

Charlotte Gainsbourg as Mary Rivers

Danny Huston as Michael Peck

Melissa Leo as Marianne Jordan

Clea DuVall as Claudia

Carly Nahon as Cathy

Claire Pakis as Laura

Nick Nichols as Boy

John Rubinstein as Gynecologist

Eddie Marsan as Reverend John

Loyd Keith Salter as Fat Man

Antef A. Harris as Basketball Guy

Marc Musso as Freddy

Teresa Delgado as Gina

Trent Dee as Guard

Tony Guyton as Guard #2

Wayne E. Beech, Jr. as Inmate #1

Keith Lamont Johnson as Inmate #2

David Chattam as Caddie #1

John Boyd West as Caddie #2

Jeff Schmidt as Caddie #3

Tony Vaughn as Al

Paul Calderon as Brown

Denis O'Hare as Dr. Rothberg

Anastasia Herin as Dolores

Carlo Alban as Lucio

Hai Quang Tran as Cashier

Annie Corley as Trish

Sharon Bishop as Receptionist

Jerry Chipman as Cristina's Father

Tom Irwin as Dr. Jones

Roberto Medina as Dr. Molina

Arita Trahan as Dr. Badnews

Rodney Ingle as Barman

Catherine Dent as Ana

Kevin Chapman as Alan

Randall Hartzog as Friend #1

Verda Davenport as Friend #2

Dorothy Armstrong-Miles as Female Friend #1

Barclay Roberts as Male Friend #1

Lisa Sanchez as Wife

Stephen Bridgewater as P.I.

Michael Finnell as Fat Prisoner

Juan Corrigan as Valet

Charlie B. Brown as Night Guard

Arron Shiver as Young Doctor

Pamela Blair as Doctor

Jennifer Pfalzgraff as Nurse

Lew Temple as County Sheriff

Tricia Branch as Skinny Woman

Jessica Scott as Cocktail Waitress (uncredited)