Keira Knightley as Domino Harvey

Mickey Rourke as Ed Mosbey

Edgar Ramírez as Choco

Delroy Lindo as Claremont Williams

Mo'Nique as Lateesha Rodriguez

Christopher Walken as Mark Heiss

Lucy Liu as Taryn Miles

Mena Suvari as Kimmie

Brian Austin Green as Self

Ian Ziering as Self

Macy Gray as Lashandra Davis

Shondrella Avery as Lashindra Davis

Riz Abbasi as Alf

Dabney Coleman as Drake Bishop

Joe Nuñez as Raul Chavez

Peter Jacobson as Burke Beckett

Kel O'Neill as Francis

Jacqueline Bisset as Sophie Wynn

Dale Dickey as Edna Fender

Lew Temple as Locus Fender

Liza Lapira as Chinegro Woman

Tom Waits as Wanderer

Jerry Springer as Self

Tabitha Brownstone as Young Domino

Domino Harvey as Girl Walking from Exploding Car

Charles Paraventi as Howie Stein

Donna W. Scott as Agent Dina Wilson

Michael Papajohn as Cigliutti Goon (uncredited)

Vic Manni as Bishop Goon #1

T.K. Carter as Lester Kincaid

Frederick Koehler as Chuckie

Stanley Kamel as Anthony Cigliutti

Chad Parker as Underwater Mobster

Cheryl Francis Harrington as Outraged Woman

Ashley Monique Clark as Kee Kee Rodriguez

Patrick Kerr as DMV Manager

Adam Clark as Agent Eric Cosgrove

Michael Andolini as Mobster

Janet Gonzalez as Louise Maldonado

Mike G. as Hector Maldonado

Eddie Hernandez as Larenz 'Creep' Dexter

Mark Newsom as Dr. Waldman

Jack McGee as Detective Chris Cudlitz

Rolando Molina as Security Manager

Morgan Nagler as Stacee Stevens

Ginger Kinison as Ariana Bower

Andy Milder as FBI Agent #1

Neal Matarazzo as FBI Agent #2

Michelle Fabiano as Mrs. Cigliutti

Phillip Darlington as Zendejas

Celesta Hodge as Runway Model

Julian Berlin as Sorority Girl

Jackson Bolt as Bounty Hunter (uncredited)

Heidi Hawking as Entertainer (uncredited)

Lora Witty as Nanny (uncredited)

Anthony Delan as Gas Attendant