Dwayne Johnson as Boxer Santaros / Jericho Cane

Seann William Scott as Roland Taverner / Ronald Taverner

Sarah Michelle Gellar as Krysta Kapowski / Krysta Now

Mandy Moore as Madeline Frost-Santaros

Justin Timberlake as Private Pilot Abilene

Miranda Richardson as Nana Mae Frost

Wallace Shawn as Baron Von Westphalen

Bai Ling as Serpentine

Nora Dunn as Cyndi Pinziki

John Larroquette as Vaughn Smallhouse

Kevin Smith as Simon Theory

Amy Poehler as Veronica Mung / Dream

Wood Harris as Dion Element

Zelda Rubinstein as Dr. Katarina Kuntzler

Beth Grant as Dr. Inga Von Westphalen

Janeane Garofalo as General Teena MacArthur

Cheri Oteri as Zora Charmichaels

Jon Lovitz as Bart Bookman

Holmes Osborne as Senator Bobby Frost

Will Sasso as Fortunio Balducci

Christopher Lambert as Walter Mung

Lou Taylor Pucci as Martin Kefauver

Michele Durrett as Starla Von Luft

Jill Ritchie as Shoshana Kapowski

Lisa K. Wyatt as Teri Riley

Curtis Armstrong as Dr. Soberin Exx

Todd Berger as Bing Zinneman

Rebekah Del Rio as Vanessa Vera Cruz

Abbey DiGregorio as Sheena Gee

Sab Shimono as Hideo Takehashi

Robert Benz as Tab Taverner

Joe Campana as Brandt Huntington

Chris Andrew Ciulla as UPU 4 Officer 3

Aaron Dillar as Jimmy Hermosa

Shari Dunn as USI Dent Reporter

Jon Falcone as Soldier Falcon

Jaret Gardiner as Shane Laverne

Shannon Lee Holmes as Todd Zinneman

Katherine Kendall as Megazeppelin Waitress

Jinah Kim as Dr. Linda Lao

Gianna Luchini as Deena Storm

Mike Nielsen as Kenny Chan

Kevin Robertson as Seamus Storm

Philip Sternberg as Dennis Voogler

Sarah Christine Smith as Dancer #1

Nicole Sciacca as Dancer #2

Aliane Baquerot as Dancer #3

Becca Sweitzer as Dancer #4

Chi Johnson as Dancer #5

Jenna Stewart as Dancer #6

Rachael Markarian as Dancer #7

Marcy McCusker as Dancer #8

Dave Carlin as News Reporter

Katarina Hyde as Isabella / Interpreter

Sharon Jordan as Secretary

Sean LoGrasso as US Ident Worker

Paulah May as Hysterical Passenger

Matt McColm as Bar Bouncer

John T. O'Brien as SWAT Team Officer

Philip Roosevelt as Homeless Terrorist

Eli Roth as Man Who Gets Shot on Toilet

Gary Sievers as Homeless Terrorist