Jon Heder as Roger Waddell

Billy Bob Thornton as Dr. P

Jacinda Barrett as Amanda Richards

Sarah Silverman as Becky

Michael Clarke Duncan as Lesher

David Cross as Ian

Horatio Sanz as Diego

Matt Walsh as Walsh

Todd Louiso as Eli

Ben Stiller as Lonnie Ratcliff

Luis Guzmán as Sergeant Moorehead

Dan Fogler as Zack

DeRay Davis as Bee Bee

Jon Glaser as Ernie

Paul Scheer as Little Pete

Joanne Baron as Lois

Omar J. Dorsey as Lawrence

Marcella Lowery as Mrs. Washington

Leonard Earl Howze as Classmate

Jim Parsons as Classmate

Aziz Ansari as Classmate

Remy K. Selma as Classmate

Andy Daly as Classmate

Bob Stephenson as Classmate

Jack Kehler as Classmate

Noel Gugliemi as Subway Guy

Daniel Venegas as Subway Guy

Jessica Stroup as Eli's Wife

Lizz Carter as Flight Attendant

Steve Monroe as Flight Attendant

Malika as Margaret (uncredited)

Khadijah Haqq McCray as Mindy (uncredited)

Nicole Randall Johnson as Shanice (uncredited)

Che Landon as Waitress (uncredited)

Chris Rubio as Airplane Passenger (uncredited)

Bernadette Birkett as Woman (uncredited)