Bonnie Bedelia as Latrelle Williamson

Caroline Rhea as Noleta Nethercott

Leslie Jordan as Earl 'Brother Boy' Ingram

Dale Dickey as Sissy Hickey

Whoopi Goldberg as Abernatha Coleman

Newell Alexander as Wardell 'Bubba' Owens

Rosemary Alexander as Dr. Eve Bolinger

David Cowgill as Odell Owens

Kirk Geiger as Ty Williamson

Sarah Hunley as Juanita Bartlett

Lorna Scott as Vera Lisso

David Steen as G.W. Nethercott

Ann Walker as LaVonda DuPree

Emerson Collins as Billy Joe Dobson

Carole Cook as Hortense

Katherine Bailess as Greta Waring

Michael MacRae as Wilson

Levi Kreis as Jimmy Ray Brewton

Scott Presley as Roger

Aleks Paunovic as Hardy

T. Ashanti Mozelle as Kyle

Alec Mapa as Marty Wells

Sharon Garrison as Mrs. Barnes

Ron Corning as Newscaster

James Love as Cassie Nova

Krystal Summers as Self

Richard D. Curtin as Edna Jean Robinson

Blake McIver Ewing as Peter

Mitchell Gold as Self

Cynthia Sanders as Nurse Sample

Thanya Romero as Leticia

Louise Beard as Aunt Little Neecy

Helen de Paiva as Evelyn Crawley