Liam Hemsworth as Jake Morrison

Jeff Goldblum as David Levinson

Jessie T. Usher as Dylan Hiller

Bill Pullman as President Whitmore

Maika Monroe as Patricia Whitmore

Travis Tope as Charlie Miller

AngelaBaby as Rain Lao

Charlotte Gainsbourg as Dr. Catherine Marceaux

Judd Hirsch as Julius Levinson

William Fichtner as General Adams

Brent Spiner as Dr. Brakish Okun

Sela Ward as President Lanford

Chin Han as Commander Jiang Lao

Patrick St. Esprit as Secretary of Defense

Vivica A. Fox as Dr. Jasmine Hiller

Deobia Oparei as Dikembe

Nicolas Wright as Floyd Rosenberg

Gbenga Akinnagbe as Agent Matthew Travis

Robert Loggia as General Grey

John Storey as Dr. Isaacs

Joey King as Sam

Jenna Purdy as Voice of Sphere

Garrett Wareing as Bobby

Hays Wellford as Felix

Mckenna Grace as Daisy

James A. Woods as Lt. Ritter

Robert Neary as Captain McQuaide

Joshua Mikel as Armand

Joel Virgel as Jaques

Arturo del Puerto as Bordeaux

Matthew Munroe as Prison Tech

Jacob Browne as Prison Tech

Ryan Cartwright as Officer Ryan Collins

Travis Hammer as Jeffrey Fineman

Lance Lim as Kevin

Zeb Sanders as Camper Henry

Donovan Tyee Smith as Camper Marcus

Stafford Douglas as Flight Officer

Jade Scott Lewis as Salt Flat Tech

Beth Bailey as Nurse

Mona Malec as DC Hospital Nurse

Omar Diop as African Guard

Ron Yuan as Yeong

Grace Huang as Lin Tang

Stephen Oyoung as Young Man

J.P. Murrieta as Local Reporter

Casey Messer as Local Reporter

Ben Wang as Chinese President

Nicholas Ballas as French President

Jonathan Richards as British Prime Minister

Ivan G'Vera as Russian President

Sam Quinn as Radar Officer

Richard Beal as Military Brass (uncredited)

Alice Rietveld as Secret Service Agent (uncredited)

Alma Sisneros as Aide 2 (uncredited)

Kenny Leu as Ping Li (uncredited)

Monique Candelaria as Tech Officer (uncredited)

Leilei Chen as Background (uncredited)

Ava Del Cielo as Young Mother (uncredited)

Diana Gaitirira as Comms Officer (uncredited)

Evan Bryn Graves as Pilot P. Goodman (uncredited)

Jason E. Hill as Marine (uncredited)

Catharine E. Jones as Flight Officer (uncredited)

Tyler Kurtz as Pilot (uncredited)

Aaron Tyler as Tug Pilot (uncredited)

Michael Davis as Old Man with Oxygen

Johnny Otto as Secret Service Agent (uncredited)

John Christian Love as Officer

Kelly V. Lucio as Singapore Pedestrian (uncredited)

Michael Love Toliver as Moon Base Tech (uncredited)