Kamal Haasan as Rajaraman Venkatraman (Vasool Raja)

Prakash Raj as Dr. Vishwanathan

Prabhu as Vatti

Sneha as Janaki Vishwanathan (Paapu)

Nagesh as Sriman Venkatraman

Rohini Hattangadi as Kasturi

Crazy Mohan as Professor Margabandhu

Karunas as Amit

Jayasurya as Zakir

Malavika as Priya

Ajay Rathnam as Medicine Professor

Kavithalaya Krishnan as Surgery Professor

Nithin Sathya as Neelakandan

Chitra Lakshmanan as Dr. Kalidas

Thalaivasal Vijay as Doctor

Santhana Bharathi as Gangadharan

Kaaka Radhakrishnan as Margabandhu's father

A. K. Veerasamy as Hospital cleaner

Madhan Bob as Mani Raja

Vaiyapuri as Piles Patient

E. Ramadoss as Ward Boy

Karate Raja as Raja's sidekick

Sampath Ram as Raja's sidekick

Meera Krishnan as Mani Raja's wife

Kaajal Pasupathi as Nurse

Boys Rajan as Professor

Yatin Karyekar as Anand

Thiruppaachi Benjamin as Pickpocket

Scissor Manogar as

Ragasiya as Dancer in the song "Cheena Thaana"