Johnny Depp as Raoul Duke

Benicio del Toro as Dr. Gonzo

Tobey Maguire as Hitchhiker

Michael Lee Gogin as Uniformed Dwarf

Larry Cedar as Car Rental Agent - Los Angeles

Brian Le Baron as Parking Attendant

Katherine Helmond as Desk Clerk at Mint Hotel

Michael Warwick as Bell Boy

Craig Bierko as Lacerda

Tyde Kierney as Reporter

Mark Harmon as Magazine Reporter

Tim Thomerson as Hoodlum

Richard Riehle as Dune Buggy Driver

Ransom Gates as Dune Buggy Passenger

Frank Romano as Dune Buggy Passenger

Gil Boccaccio as Desert Room Doorman

Gary Bruno as Desert Room Doorman

Richard Portnow as Wine Colored Tuxedo

Debbie Reynolds as Debbie Reynolds (voice)

Steve Schirripa as Goon

Verne Troyer as Wee Waiter

Will Blount as The Black Guy

Ben Yeagar as Clown Barker

Penn Jillette as Carnie Talker

Christopher Callen as Bazooko Circus Waitress

Cameron Diaz as Blonde TV Reporter

Benjamin A. Van Der Veen as TV Crew Man

Lyle Lovett as Road Person

Flea as Musician

Alex Craig Mann as Stockbroker

Gregory Itzin as Mint Hotel Clerk

Gary Busey as Highway Patrolman

Troy Evans as Police Chief

Gale Baker as Police Chief's Wife

Christopher Meloni as Clerk at Flamingo Hotel

Christina Ricci as Lucy

Chris Hendrie as Executive Director

Larry Brandenburg as Cop in Car

Michael Jeter as Ron Bumquist

Donald Morrow as Film Narrator (voice)

Harry Dean Stanton as Judge

Jenette Goldstein as Maid

Stephen Bridgewater as Human Cannonball

Buck Holland as Shopper

Mary Gillis as Shopper

Jennifer Elise Cox as Shopper

Robert Allen as Car Rental Agent - Los Angeles

David Brisbin as Man in Car

Ellen Barkin as Waitress at North Star Cafe

James O'Sullivan as TV Newsman

Milt Tarver as TV Newsman

Kathryn Alexander as Lizard Performer

Mia Babalis as Lizard Performer

Kristin Draudt as Lizard Performer

Kim Flowers as Lizard Performer

Trudi Forristal as Lizard Performer

Nan Friedman as Lizard Performer

Judith Lieff as Lizard Performer

Tane McClure as Lizard Performer

Diana Mehoudar as Lizard Performer

Geoffrey Nimmer as Lizard Performer

Marlene Bologna as Trapeze Artist

Chobi Gyorgy as Trapeze Artist

Karen Price as Trapeze Artist

Lisa Hoyle as Trapeze Artist

Joseph S. Griffo as Trapeze Artist

Laraine Newman as Frog-Eyed Woman (uncredited)

Hunter S. Thompson as Other Duke in Matrix Flashback (uncredited)