Jerry O'Connell as Clark Kent / Superman (voice)

Rebecca Romijn as Lois Lane (voice)

Rainn Wilson as Lex Luthor (voice)

Rosario Dawson as Diana Prince / Wonder Woman (voice)

Nathan Fillion as Hal Jordan / Green Lantern (voice)

Christopher Gorham as Barry Allen / The Flash (voice)

Matt Lanter as Arthur Curry / Aquaman (voice)

Shemar Moore as Victor Stone / Cyborg (voice)

Nyambi Nyambi as Martian Manhunter (voice)

Jason O'Mara as Bruce Wayne / Batman (voice)

Jonathan Adams as Mayor (voice)

Rocky Carroll as Silas Stone (voice)

Trevor Devall as Dabney Donovan / Bruno Mannheim (voice)

Paul Eiding as Pa Kent (voice)

Jennifer Hale as Ma Kent (voice)

Patrick Fabian as Hank Henshaw (voice)

Charles Halford as Bibbo Bibbowski (voice)

Erica Luttrell as Mercy Graves (voice)

Max Mittelman as Jimmy Olsen (voice)

Toks Olagundoye as Cat Grant (voice)

Rick Pasqualone as Dan Turpin (voice)

Amanda Troop as Maggie Sawyer (voice)

Cress Williams as John Henry Irons (voice)