Christian Slater as Floyd Lawton / Deadshot (voice)

Tara Strong as Harleen Quinzel / Harley Quinn (voice)

Billy Brown as Ben Turner / Bronze Tiger (voice)

Liam McIntyre as George Harness / Captain Boomerang (voice)

Vanessa Williams as Amanda Waller (voice)

Kristin Bauer as Crystal Frost / Killer Frost (voice)

Gideon Emery as Sameer Park / Copperhead (voice)

C. Thomas Howell as Eobard Thawne / Professor Zoom (voice)

Greg Grunberg as Steel Maxum (voice)

Julie Nathanson as Siobhan Smythe / Silver Banshee (voice) / Jewelee (voice)

Dave Fennoy as Blockbuster (voice) / Tobias Whale (voice) / Black Manta (voice)

Dania Ramirez as Scandal Savage (voice)

Cissy Jones as Knockout (voice) / Female Announcer (voice)

James Urbaniak as Lazlo Valentin / Professor Pyg (voice)

Jim Pirri as Vandal Savage (voice) / Werner Zytle / Count Vertigo (voice)

Natalie Lander as Darma (voice)

Trevor Devall as Punch (voice) / Thug #1 (voice)

David Boat as Harvey Dent / Two-Face (voice) / Thug #2 (voice)

Matthew Mercer as Savage Gunman / Argus Scientist / Belle Reve Doctor (voice)