Sheri Moon Zombie as Baby Firefly

Bill Moseley as Otis Driftwood

Richard Brake as Winslow Foxworth Coltrane

Emilio Rivera as Aquarius

Sid Haig as Captain Spaulding

Jeff Daniel Phillips as Warden Virgil Harper

Dee Wallace as Greta

Richard Edson as Carlos Perro

Danny Trejo as Rondo

Kevin Jackson as Gerard James

Pancho Moler as Sebastian

Steven Michael Quezada as Diego

Clint Howard as Mr. Baggy Britches

Barry Bostwick as Narrator

Dot-Marie Jones as Slackjaw

Richard Riehle as Sheriff Wolf

David Ury as Travis O'Rourke

Sean Whalen as Burt Willie

Tom Papa as News Anchor George Glass

Daniel Roebuck as Morris Green

Sylvia Jefferies as Heather Starship Galen

Tracey A. Leigh as Judy Harper

Anny Rosario as Juanita

Austin Stoker as Newscaster Gibson

Bill Oberst Jr. as Tony Commando

Lucinda Jenney as Nebraska

Christopher B. Duncan as Glassy Wolf

Wade Williams as Buford Tuttle

Billy Blair as Garbage Man

Jan Hoag as Guard Betty Lou

Tomas Boykin as Derek Zoom

Stacie Greenwell as Janice

Rob Welsh as Luke

Matthew Willig as Creep

Flor de Maria Chahua as Bella

Duane Whitaker as Dr. Bankhead (uncredited)

Noel Gugliemi as Bullet

Mariano Mendoza as Gonzo

Nancy Linehan Charles as Dr. Bowman

Jackie S. Garcia as Princesa