Sid Haig as Captain Spaulding / James Cutter

Bill Moseley as Otis B. Driftwood

Sheri Moon Zombie as Baby Firefly / Vera-Ellen

William Forsythe as Sheriff John Quincy Wydel

Ken Foree as Charlie Altamont

Matthew McGrory as Tiny Firefly

Leslie Easterbrook as Mother Firefly

Geoffrey Lewis as Roy Sullivan

Priscilla Barnes as Gloria Sullivan

Dave Sheridan as Officer Ray Dobson

Kate Norby as Wendy Banjo

Lew Temple as Adam Banjo

Danny Trejo as Rondo

Page Falkinburg Jr. as Billy Ray Snapper

E. G. Daily as Candy

Tom Towles as Lieutenant George Wydell

Michael Berryman as Clevon

P. J. Soles as Susan

Deborah Van Valkenburgh as Casey

Ginger Lynn Allen as Fanny

Mary Woronov as Abbie

Daniel Roebuck as Morris Green

Duane Whitaker as Dr. Bankhead

Steve Railsback as Sheriff Ken Dwyer

Tyler Mane as Rufus

Brian Posehn as Jimmy

Michael 'Red Bone' Alcott as Darrell

Chris Ellis as Coggs

Kane Hodder as Officer with Gas Mask (uncredited)

Jessica Helmer as Otis' Victim (uncredited)

Kelvin Brown as Bubba