Margot Robbie as Harley Quinn

Rosie Perez as Renee Montoya

Mary Elizabeth Winstead as Helena Bertinelli / Huntress

Jurnee Smollett as Dinah Lance / Black Canary

Ewan McGregor as Roman Sionis

Ella Jay Basco as Cassandra Cain

Chris Messina as Victor Zsasz

Ali Wong as Ellen Yee

David Ury as Sleazy Breeder

Sara Montez as Shallow Friend #1 / Kathrine

Izabel Pakzad as Shallow Friend #2

Daniel Bernhardt as Sionis' Chauffeur

Kc Strubbe as Naïve Teammate

Jacky Shu as Skeptical Teammate

Paloma Esparza Rabinov as Bitchy Teammate

Derek Wilson as Detective Tim Munroe

Joe Bucaro III as Carlos Rossi

James Henry Williams Jr. as Ace Chemical Police Officer

François Chau as Mr. Keo

Miyuki Matsunaga as Mrs. Keo

Anna Mikami as Miss Keo (16 yrs)

Bruno Oliver as Bodega Cook (Sal)

Keisha Tucker as Roller Derby Girl

Matthew Willig as Happy

Jeremy Denzlinger as Desk Sergeant

Michael Masini as Officer Drago

Charles Carpenter as Processing Officer

Daniel Cole as Patrol Cop

Jesse Bush as Patrol Cop

Steven Williams as Captain Patrick Erickson

Charlene Amoia as Maria Bertinelli

Paul Lasa as Helena's Father

Ella Mika as Young Helena

Robert Catrini as Stefano Galante

Eddie Alfano as Helena's Bodyguard

Chris Carnel as Desk Sergeant

Buddy Sosthand as Coffee Cup Cop

Tim Sitarz as Donut Cop

Shawn Balentine as Key Card Cop

Shahaub Roudbari as Smarmy Guy

Pramod Kumar as Irate Shopkeeper

Christine Engh as Elderly Woman

K.K. Barrett as Dr. Aguilar

David Bianchi as Sionis Henchman #1

Simon Rhee as Cell Guard

Terrence Julien as Cell Guard

George Crayton as Prisoner

Caleb Spillyards as Prisoner

Qiang Li as Prisoner

Anthony N. as Prisoner

Sala Baker as Prisoner

Christian Womack as Prisoner

Bryan Sloyer as Prisoner

Kofi Yiadom as Mercenary

Efka Kvaraciejus as Mercenary

Sam Hargrave as Mercenary

Dennis Keiffer as Mercenary

Dana Lee as Doc

Bojana Novaković as Erika

Andy Hoff as Erika's Date

Eric Michael Cole as Disgruntled Man

Oakley Lehman as Mercedes Gang

Richard King as Mercedes Gang

Tim Rigby as RR Passenger

Judy Kain as Bespectacled Secretary (uncredited)

Rj Wayne as Tough Guy (uncredited)

Zack Whyel as Roman's Healer (uncredited)

Ellay Watson as Roller Derby Fan (uncredited)

Karen Teliha as Nun (uncredited)

Nev Smith as Gotham Detective (uncredited)

Greice Santo as Scantily Clad Crystal (uncredited)

Zeus Sagittarius as Roman's Goon (uncredited)

Talon Reid as Roman's Goon (uncredited)

Matthew Parry-Jones as Club Goer (uncredited)

Brian Nuesi as Husband (uncredited)

Adinett Nsabimana as Girl at the Bar (uncredited)

Brandon Garic Notch as Roman's Lift Goon (uncredited)

Anthony Molinari as Mafiosi (uncredited)

Ego Mikitas as Don (uncredited)

Lenora May as Mrs. Marcucci (uncredited)

Jeff Lipary as BBB Gang Member (uncredited)

Brandon Irvin as Roman's Goon (uncredited)

Damon Hoffman as Bodybuilder (uncredited)

William Guirola as Thug (uncredited)

Nico Greetham as Young Goon (uncredited)

Luis Richard Gomez as Harley Super Fan (uncredited)

Shad Gaspard as Lords Leader (uncredited)

Julian Garcia as Roman's Goon (uncredited)

Eddie J. Fernandez as Gauntlet Cop (uncredited)

Mike Ferguson as Lord of the Avenue (uncredited)

Gerald Downey as Judge (uncredited)

Jack Dourakos as Club Goer (uncredited)

Sadyr Diouf as Roman's Goon (uncredited)

Joey Courteau as Club Dancer (uncredited)

Dan Cole as Officer Timm (uncredited)

Lucas Di Medio as Roman's Bodyguard (uncredited)

Jason Catron as Sprang Bridge Soldier (uncredited)

David Anthony Buglione as Joe Bertinelli (uncredited)