Dwayne Johnson as Dr. Smolder Bravestone

Kevin Hart as Franklin 'Mouse' Finbar

Jack Black as Professor Sheldon 'Shelly' Oberon

Karen Gillan as Ruby Roundhouse

Awkwafina as Ming

Nick Jonas as Jefferson 'Seaplane' McDonough

Alex Wolff as Spencer Gilpin

Morgan Turner as Martha Kaply

Madison Iseman as Bethany

Ser'Darius Blain as Anthony 'Fridge' Johnson

Danny DeVito as Eddie

Danny Glover as Milo

Rhys Darby as Nigel Billingsley

Colin Hanks as Alex

Rory McCann as Jurgen the Brutal

Marin Hinkle as Spencer's Mom

Vince Pisani as Pharmacy Manager

Dorothy Steel as Village Elder

Jennifer Patino as Bravestone's Mother

Madison Johnson as Little Bethany Vreeke

Dania Ramirez as Lady in Red

Derek Russo as Key Master

Nick Gomez as Oasis Drunk

Massi Furlan as Switchblade

Javier Villamil as Switchblade's Sidekick

Anthony Neves as Jurgen's Patrolman

Morgan Brown as Fortress Guard

Deobia Oparei as Elevator Guard

Leslie Simms as Cake Lady

John Ross Bowie as Cavendish

Lucy DeVito as Maiden

Bebe Neuwirth as Nora

Lamorne Morris as Heater Repair Guy

Darin Ferraro as The Gun Seller (uncredited)

Sal Longobardo as Tony (uncredited)

Michael Beasley as Coach Davis (uncredited)

Charles Green as Bartender (uncredited)

James William Ballard as Bad Guy in Fortress (uncredited)

Kodai Yamaguchi as Jumanjian Villager (uncredited)

Ashley Scott as Ashley (uncredited)

Melissa Kennemore as Marauder 1 / Jergens Inner Circle (uncredited)

Vanessa Cater as Red Headed Marauder (uncredited)

John David Bulla as Groovy Face Tattoo Biker (uncredited)

Ryan Cheeseman as Marauder (uncredited)

Cruz Abelita as Messenger Boy (uncredited)

Sheril Rodgers as New York City Pedestrain (uncredited)

Bruno Rose as NY Dorm Guy (uncredited)