Catherine Keener as Amelia

Anne Heche as Laura

Todd Field as Frank

Liev Schreiber as Andrew

Kevin Corrigan as Bill

Amy Braverman as Young Amelia

Miranda Rhyne as Young Laura

Randall Batinkoff as Peter

Brenda Denmark as The Vet

Vincent Pastore as Laura's Devil-Seeing Patient

Joseph Siravo as Amelia's Therapist

Rafa Alvarez as Laura's Sexy Patient

Ritamarie Kelly as Ellen

Steve Cohen as Actor In Play

Jordan Levinson as Peter's Friend

Heather Gottlieb as Amelia's Co-Worker

Lynn Cohen as Andrew's Mom

Lawrence Holofcener as Andrew's Dad

Nitza Wilon as Cat Sympathizer

Allison Janney as Gum Puller

Alice Drummond as Betsy

Bettina Skye as Virginia

Michael Kroll as Rick

Isa Thomas as Aunt Cynthia