Russell Brand as E.B (voice)

James Marsden as Fred

Kaley Cuoco as Samantha O'Hare

Hank Azaria as Carlos / Phil (voice)

Elizabeth Perkins as Bonnie O'Hare

Gary Cole as Henry O'Hare

Hugh Laurie as E.B.'s Dad (voice)

David Hasselhoff as David Hasselhoff

Chelsea Handler as Mrs. Beck

Dustin Ybarra as Cody

Tiffany Espensen as Alex O'Hare

Jimmy Carter as Blind Boys of Alabama

Veronica Alicino as Waitress

Coleton Ray as Young Fred

Mark Riccardi as Security Guard

Greg Lewis as Performer

Hugh Hefner as Voice at Playboy Mansion (voice)

Rick Pasqualone as Utility Voice

Django Marsh as Young E.B. (voice)

Robbie Tucker as Kid#1 (uncredited)

Crystal the Monkey as Monkey (uncredited)

Michaël Grégorio as (voice) (uncredited)