Robert Davi as Det. Sean McKinney

Caitlin Dulany as Dr. Susan Fowler

Gretchen Becker as Kate Sullivan

Paul Gleason as Hank Cooney

Jackie Earle Haley as Frank Jessup

Julius Harris as Houngan

Grand L. Bush as Willie

Doug Savant as Dr. Peter Myerson

Bobby Di Cicco as Bishop

Frank Pesce as Tribble

Robert Z'Dar as Matt Cordell

Robert Forster as Dr. Powell

Lou Casal as Leon

Brenda Varda as Lindsey

Vanessa Marquez as Terrry

Denney Pierce as Pedestrian Heckler

Ted Raimi as Reporter

Vinnie Curto as Kenyon

Jophery C. Brown as Degrazia

Jeffrey Anderson-Gunter as Janitor

Jeffrey Hylton as Teen Witness

Barbara Pilavin as Nora Sullivan

Vic Manni as Shotgun Cop

Tony Capozzola as Nelson

Barry Livingston as Asst. Coroner

Jason Lustig as EMT Driver

Bill Irving as Elderly Patient

Harri James as Radiation Therapist

Katherine Marie Elledge as Nurse

Amanda Finnigan as Dr. Dennison

Claudia Templeton as Dr. Chad

Hillary Black as Dr. Everett

Henry Fehren as Priest

Andy Gill as Driver on Fire