Johnny Depp as Ed Wood

Martin Landau as Bela Lugosi

Sarah Jessica Parker as Dolores Fuller

Patricia Arquette as Kathy O'Hara

Jeffrey Jones as Criswell

G. D. Spradlin as Reverend Lemon

Vincent D'Onofrio as Orson Welles

Bill Murray as Bunny Breckinridge

Mike Starr as Georgie Weiss

Max Casella as Paul Marco

Brent Hinkley as Conrad Brooks

Lisa Marie as Vampira

Jim Myers as Tor Johnson

Juliet Landau as Loretta King

Clive Rosengren as Ed Reynolds

Norman Alden as Cameraman Bill

Leonard Termo as Makeup Man Harry

Ned Bellamy as Dr. Tom Mason

Danny Dayton as Soundman

Ross Manarchy as Camera Assistant

Bill Cusack as Tony McCoy

Aaron Nelms as Teenage Kid

Biff Yeager as Rude Boss

Joseph R. Gannascoli as Security Guard

Carmen Filpi as Old Crusty Man

Lisa Malkiewicz as Secretary #1

Melora Walters as Secretary #2

Conrad Brooks as Bartender

Don Amendolia as Salesman

Tommy Bertelsen as Tough Boy

Reid Cruickshanks as Stage Guard

Stanley DeSantis as Mr. Feldman

Lionel Decker as Executive #1

Edmund L. Shaff as Executive #2

Gene LeBell as Ring Announcer

Bobby Slayton as TV Show Host

Gretchen Becker as TV Host's Assistant

John Rice as Conservative Man

Catherine Butterfield as Conservative Wife

Mary Portser as Backer's Wife

King Cotton as Hick Backer

Don Hood as Southern Backer

Frank Echols as Doorman

Matthew Barry as Valet

Ralph Monaco as Waiter

Anthony Russell as Busboy

Tommy Bush as Stage Manager

Gregory Walcott as Potential Backer

Charles C. Stevenson Jr. as Another Backer

Rance Howard as Old Man McCoy

Vasek Simek as Professor Strowski

Alan Martin as Vampira's Assistant

Salwa Ali as Vampira's Girlfriend

Rodney Kizziah as Vampira's Friend

Korla Pandit as Indian Musician

Hannah Eckstein as Greta Johnson

Luc De Schepper as Karl Johnson

Vinny Argiro as TV Horror Show Director

Patti Tippo as Nurse

Ray Baker as Doctor

Louis Lombardi as Rental House Manager

Jim Boyce as Theatre Manager

Ben Ryan Ganger as Angry Kid

Ryan Holihan as Frantic Usher

Marc Revivo as High School Punk

Charlie Holliday as Tourist

Adam Drescher as Photographer #1

Ric Mancini as Photographer #2

Daniel Riordan as Pilot / Strapping Young Man

Mickey Cottrell as Hammy Alien

Christopher George Simpson as Organist

Robert Binford as Choir Member

Herbert Boche as Choir Member

Linda Rae Brienza as Choir Member

Marlene Cook as Choir Member

Sylvia Coussa as Choir Member

Audrey Cuyler as Choir Member

Joseph Golightly as Choir Member

Carrie Starner Hummel as Choir Member

Ramona Kemp-Blair as Choir Member

Carolyn Kessinger as Choir Member

Nancy Longyear as Choir Member

Matthew Nelson as Choir Member

Robert Nuffer as Choir Member

William Michael Short as Choir Member

Susan Eileen Simpson as Choir Member

George F. Sterne as Choir Member

Charles Alan Stephenson as Choir Member

Cheri A. Williams as Choir Member

Cynthia Ann Wilson as Choir Member

Maurice LaMarche as Orson Welles (voice) (uncredited)

Jesse Hernandez as Wrestling Opponent

Lena Banks as Sexy Pedestrian (uncredited)

Ada Tai as Vampira's Friend (uncredited)

Arlene Tai as Vampira's Friend (uncredited)

Rayder Woods as Car Vandal (uncredited)

Bill Blair as Carny (uncredited)

Bill Anderson as Wrestling Referee (uncredited)

Eugenie Bondurant as Dagmar (uncredited)

Mike Breyer as Photographer (uncredited)

Patrick Cranshaw as Editor on Studio Lot (uncredited)

Ryal Haakenson as Wedding Guest / Theatre Goer (uncredited)

Zachary Keats as Trick-or-Treating Kid (uncredited)

Susan Knego as Girl in Theater Lobby (uncredited)

Navya La Shay as Secretary (uncredited)

Tanya Marten as Secretary (uncredited)

Gorja Max as Bra Stuffing Transvestite (uncredited)

Johnny Meyer as Kid At Movie Theater (uncredited)

John Michael Quinn as Minister (uncredited)

Michael Satterfield as Taxi Driver (uncredited)

Jeff Shrewsbury as Theater Patron (uncredited)

Richard Yett as Wrap Party Guest (uncredited)