Johnny Depp as Ed Wood

Martin Landau as Bela Lugosi

Sarah Jessica Parker as Dolores Fuller

Patricia Arquette as Kathy O'Hara

Jeffrey Jones as Criswell

Bill Murray as Bunny Breckinridge

Lisa Marie as Vampira

Jim Myers as Tor Johnson

G. D. Spradlin as Reverend Lemon

Vincent D'Onofrio as Orson Welles

Mike Starr as Georgie Weiss

Max Casella as Paul Marco

Brent Hinkley as Conrad Brooks

Juliet Landau as Loretta King

Clive Rosengren as Ed Reynolds

Norman Alden as Cameraman Bill (uncredited)

Leonard Termo as Makeup Man Harry (uncredited)

Ned Bellamy as Dr. Tom Mason (uncredited)

Danny Dayton as Soundman (uncredited)

Ross Manarchy as Camera Assistant (uncredited)

Bill Cusack as Tony McCoy

Stanley DeSantis as Mr. Feldman (uncredited)

Biff Yeager as Rude Boss (uncredited)

Joseph R. Gannascoli as Security Guard (uncredited)

Carmen Filpi as Old Crusty Man (uncredited)

Lisa Malkiewicz as Secretary #1 (uncredited)

Melora Walters as Secretary #2 (uncredited)

Conrad Brooks as Bartender (uncredited)

Don Amendolia as Salesman (uncredited)

Reid Cruickshanks as Stage Guard (uncredited)

Lionel Decker as Executive #1 (uncredited)

Edmund L. Shaff as Executive #2 (uncredited)

Gene LeBell as Ring Announcer (uncredited)

Bobby Slayton as TV Show Host (uncredited)

Gretchen Becker as TV Host's Assistant (uncredited)

John Rice as Conservative Man (uncredited)

Catherine Butterfield as Conservative Wife (uncredited)

Mary Portser as Backer's Wife (uncredited)

King Cotton as Hick Backer (uncredited)

Don Hood as Southern Backer (uncredited)

Matthew Barry as Valet (uncredited)

Ralph Monaco as Waiter (uncredited)

Anthony Russell as Busboy (uncredited)

Gregory Walcott as Potential Backer (uncredited)

Charles C. Stevenson Jr. as Another Backer (uncredited)

Rance Howard as Old Man McCoy (uncredited)

Vasek Simek as Professor Strowski (uncredited)

Vinny Argiro as TV Horror Show Director (uncredited)

Korla Pandit as Indian Musician (uncredited)

Patti Tippo as Nurse (uncredited)

Ray Baker as Doctor (uncredited)

Louis Lombardi as Rental House Manager (uncredited)

Jesse Hernandez as Wrestling Opponent (uncredited)

Jim Boyce as Theatre Manager (uncredited)

Ben Ryan Ganger as Angry Kid (uncredited)

Charlie Holliday as Tourist (uncredited)

Tommy Bertelsen as Tough Boy (uncredited)

Adam Drescher as Photographer #1 (uncredited)

Ric Mancini as Photographer #2 (uncredited)

Daniel Riordan as Pilot / Strapping Young Man (uncredited)

Mickey Cottrell as Hammy Alien (uncredited)

Lena Banks as Sexy Pedestrian (uncredited)

Maurice LaMarche as Orson Welles (voice) (uncredited)

Ada Tai as Vampira's Friend (uncredited)

Arlene Tai as Vampira's Friend (uncredited)

Rayder Woods as Car Vandal (uncredited)

Ralph Moratz as Extra (uncredited)

Bill Blair as Carny (uncredited)

Ryan Holihan as Frantic Usher