Emma Thompson as Katherine Newbury

Mindy Kaling as Molly Patel

Max Casella as Burditt

Hugh Dancy as Charlie Fain

Denis O'Hare as Brad

Reid Scott as Tom Campbell

Amy Ryan as Caroline Morton

Paul Walter Hauser as Mancusco

John Early as Reynolds

John Lithgow as Walter Lovell

Megalyn Echikunwoke as Robin

Ike Barinholtz as Daniel Tennant

Annaleigh Ashford as Mimi Mismatch

Halston Sage as Zoe Martlin

Marc Kudisch as Billy Katsner

Seth Meyers as Himself

Bill Maher as Himself

Jake Tapper as Himself

Maria Dizzia as Joan

Sakina Jaffrey as Molly's Mom

Luke Slattery as Hayes Campbell

Blake DeLong as McCary

David Neal Levin as Plant Manager

Paige Gilbert as Dee

Kerry Flanagan as Female Reporter

Lucas Caleb Rooney as Gabe Eichler

Rupak Ginn as Teacher

Glo Tavarez as Young Woman

Jia Patel as Pavarti