Robert Downey Jr. as Harry Lockhart

Val Kilmer as Gay Perry

Michelle Monaghan as Harmony Faith Lane

Corbin Bernsen as Harlan Dexter

Dash Mihok as Mr. Frying Pan

Larry Miller as Dabney Shaw

Rockmond Dunbar as Mr. Fire

Shannyn Sossamon as Pink Hair Girl

Angela Lindvall as Flicka

Indio Falconer Downey as Harry Age 9

Ariel Winter as Harmony Age 7

Duane Carnahan as Chainsaw Kid

Josh Richman as Rickie

Martha Hackett as Pistol Woman

Nancy Fish as NY Casting Woman

Bill McAdams Jr. as N.Y. Cop

Tanja Reichert as B-Movie Actress

Jake McKinnon as Creature

Stephanie Pearson as Teen Harmony

Christopher Gilman as Protocop

Brendan Fehily as Local News Reporter

David Newsom as Agent Type

Judie Aronson as Gift Bag Girl

Ali Hillis as Marleah

Wiley M. Pickett as Homicide Cop

Joe Keyes as Lobby Cop

Bobby Tuttle as Hotel Concierge

Jake Eberle as Patrol Cop

Saida Pagan as News Anchor

Lela Edgar as Party Girl

Daniel Browning Smith as Rubber Boy

Teresa Maria Herrera as Newswoman

Kathy Lamkin as Woman in Hospital Blues

Evan Parke as Dexter Clinic Guard

Vincent Laresca as Aurelio

Brian Simpson as Dexter Goon

Cole S. McKay as Dexter Goon

Ben Hernandez Bray as Dexter Goon

Harrison Young as Harmony's Dad

Laurence Fishburne as Bear in Genaros Beer Commercial (voice) (uncredited)

Deanna Dozier as Kristin (uncredited)