Michaela Watkins as Judy Small

Alicia Silverstone as Susan Howard

Rob Corddry as Bob Howard

Anna Pniowsky as Louise

David Paymer as Dr. Edward Kingsley

Aisha Tyler as Roxy

Sarah Shahi as Annabelle

Haley Joel Osment as Reed

Dichen Lachman as Stern

John Ross Bowie as Nick

Ginger Gonzaga as Miranda

Sunkrish Bala as Walter

Erik Griffin as Principal Sykes

Paris Bravo as Zooey

Angela Oh as Dr. Smithson

Marcelo Tubert as Dr. John

Jack Axelrod as Dr. Cherbenko

Brett Hoyle as James

Flula Borg as Serge

Craig Robert Young as Roger

Gavin Leatherwood as Spit

Chido Nwokocha as Policeman