Toni Collette as Iris Chapman

Parker Posey as Margaret J. Burrell

Lisa Kudrow as Paula

Alanna Ubach as Jane

Helen FitzGerald as Cleo

Stanley DeSantis as Art

Jamie Kennedy as Eddie

David James Elliott as Mr. MacNamee

Debra Jo Rupp as Barbara

Kevin Cooney as Mr. Kilmer

Bob Balaban as Milton Lasky

Paul Dooley as Bud Chapman

Scott Mosenson as Jack Shoberg

Irene Olga López as Coffee Lady

Joshua Malina as Global Credit Receptionist

O-Lan Jones as Madame Debbie

Joe Chrest as Detective

Patrice Pitman Quinn as Woman in Office

Michelle Arthur as Diane, the Shoe Lady

Athena Ubach as Jane's Sister

Chuck Borden as Security Guard

Sully Diaz as Waitress

Jim Wise as Man in Bar

Wendy Pitts as Saleslady

Steve Rodriguez as Lobby Guard

Jaime Gomez as Derrick

Terri Hoyos as Female Executive

Brodie Nelson as Copy Repairman

Shauna Wilson as Louise

Lynn Tufeld as Businesswoman Missing Watch

Jennifer Balgobin as Attractive Woman (uncredited)

Gregg Daniel as Policeman (uncredited)

Constance Forslund as Flight Attendant (uncredited)

Tim Hutchinson as Businessman (uncredited)

Bridget Sienna as Woman with Cop (uncredited)

Patti Yasutake as Theater Woman (uncredited)

Peter Atherton as Extra (uncredited)

Jacque Gonzales as Job Applicant (uncredited)