Michael C. Hall as Jack

Sarah Silverman as Cheri

Rainn Wilson as Joel

Ben Schwartz as Nathan

Kate Mara as Meg

Taraji P. Henson as Mary

Judy Greer as Laura

Alicia Witt as Amy

Ron Rifkin as Henry Meyerwitz

Lesley Ann Warren as Marilyn

Octavia Spencer as Alison

Rich Delia as Waiter

Stephen Tobolowsky as Ephraim

Lewis Black as Narrator (voice)

Kulap Vilaysack as Lily

Niko Novick as Paramedic (uncredited)

Nicholas Hormann as Ted

Michael McDonald as British Director

Troian Bellisario as Film Set P.A.

David Packer as Eli

Danay García as Attractive P.A.

Deborah Pratt as Cassandra Williamson

Michael Cavanaugh as Brad Thompkins

Michael Chinyamurindi as Maduk

Paige Orr as Carly

Geoffrey Arend as Dr. Novak

Dominic Flores as Salvador

Guillermo Díaz as Jesus

Lester Speight as Wizdom

Jack Plotnick as Bookstore Manager

Emily Kuroda as Nail Salon Owner

Jeff Lam as Chun

Karl Stavem as Paul the Maitre d'

David Diaan as Hari

Raja Fenske as Rajeev

Sam Carson as Man in Booth

Tom Katsis as Henry's Friend

Rita Rani Ahuja as Doctor