Chevy Chase as Al Hart

Richard Dreyfuss as Buddy Green

Andie MacDowell as Doris Lovejoy

Kate Micucci as Jeannie

Chris Parnell as Charlie Green

George Wallace as Johnny Sunshine

Lewis Black as Max Becker

Richard Kind as Jimbo

Carol Sutton as Gayle Johnson

Amy Brassette as Stand-up Comic / Show Host

Ritchie Montgomery as Texas MC

Isla Cervelli as Courtesan

Kit Willesee as Actress in Cafe

Jason Batchko as Little Leo

Belinda D'Pree as Mary Anne

Chris Fleming as Himself

Yuka Takara as Tucson Comic

Karla Garcia as Tijuana Prostitute (uncredited)

Aaron Mitchell as Truck Stop Patron (uncredited)