Charlize Theron as Mavis Gary

Patton Oswalt as Matt Freehauf

Patrick Wilson as Buddy Slade

Elizabeth Reaser as Beth Slade

Collette Wolfe as Sandra Freehauf

Jill Eikenberry as Hedda Gary

Richard Bekins as David Gary

Mary Beth Hurt as Jan

Kate Nowlin as Mary Ellen Trantowski

Jenny Dare Paulin as Nipple Confusion Bassist

Rebecca Hart as Nipple Confusion Guitarist

Louisa Krause as Front Desk Girl

Elizabeth Ward Land as Sales Lady

Brian McElhaney as Book Associate

Hettienne Park as Vicki

John Forest as Wheelchair Mike

Rightor Doyle as Babysitter

Brady Smith as Date Man

Tim Young as Champions Server

Erin Darke as Teen Employee

Jee Young Han as Teen Employee

Ella Rae Peck as Girl

Aleisha Allen as Girl

Matt Wilson as Teenage Clerk

Orlagh Cassidy as Party Guest

Charles Techman as Parking Attendant

Emily Meade as Denny's Waitress

Neil Hellegers as Young Dad

Michael Nathanson as Champions Greeter

Landyn Banx as Business Person (uncredited)

Kirsten Gregerson as Business Person (uncredited)

J.K. Simmons as Mavis' Publisher (voice) (uncredited)

Joel Thingvall as Businessman in Skyway (uncredited)

Julie E. Davis as Shopper (uncredited)

Fredrika Dukes as Business Person (uncredited)

John Edel as Businessman in Skyway (uncredited)

Rosemary Howard as Guest at Baby Naming Party (uncredited)

Eric Pierson as Restaurant Patron (uncredited)