Mélanie Thierry as Marie de Montpensier

Lambert Wilson as François de Chabannes

Gaspard Ulliel as Henri de Guise

Grégoire Leprince-Ringuet as Philippe de Montpensier

Raphaël Personnaz as Le Duc d'Anjou

Michel Vuillermoz as Le Duc de Montpensier

Philippe Magnan as Le Marquis de Mézières

Florence Thomassin as La Marquise de Mézières

Christine Brücher as La Duchesse de Montpensier

Evelina Meghnagi as Catherine de Médicis

Judith Chemla as Catherine de Guise

César Domboy as Mayenne

Jean-Pol Dubois as Le Cardinal de Lorraine

Charles Petit as Nicolas

Joséphine de la Baume as Jeanne, la suivante de Marie

Anatole de Bodinat as Joyeuse

Samuel Theis as La Valette

Eric Rulliat as Quélus

Jean-Yves Roan as Le colporteur

Nathalie Krebs as La duègne de Marie

Alain Sachs as L'aubergiste

Tomasz Białkowski as Le professeur de polonais

Jean-Claude Calon as Le tailleur du Duc

Olivier Loustau as Le brigand

Deborah Grall as La servante à l'auberge

Mathieu Lourdel as Saint-Mégrin

Frédéric Bourboulon as Un noble au Louvre

Francis Camel as Le chamelier

Frédéric Laforet as Quercy

Romain Vergnaud as Charles

Yann Vaille as Beauvais