Kangana Ranaut as 'Amma' J. Jayalalithaa

Arvind Swamy as M. J. Ramachandran

Nassar as M. Karuna

Bharathi Kannan as C.N. Annadurai

Bhagyashree as Sandhya

Samuthirakani as R. N. Veerappan

Madhoo as V. N. Janaki Ramachandran

Radha Ravi as M. R. Radha

Thambi Ramaiah as Madhavan

Poorna as Sasi

A. R. Manikandan as Moorthy

Bharath Reddy as Party Member

Vidhya Pradeep as Actress

Shanmugarajan as Valampuri John

Flora Jacob as Indira Gandhi

Rajiv Kumar Aneja as L K Advani

Regina Cassandra as Saroja

Nitya Shetty as Trainee doctor