Amy Adams as Beverly "Bev" Vance

Glenn Close as Bonnie "Mamaw" Vance

Gabriel Basso as J.D. Vance

Haley Bennett as Lindsay Vance

Freida Pinto as Usha Chilukuri

Bo Hopkins as Papaw

Owen Asztalos as Young J.D. Vance

Jesse C. Boyd as Matt

Stephen Kunken as Phillip Roseman

Keong Sim as Ken

Morgan Gao as Travis

Ethan Suess as Chris

Jono Mitchell as Kevin

Bill Kelly as Uncle Pat

David Dwyer as Uncle Arch

Sarah Hudson as Lori

Ted Huckabee as Jimmy (Bev's Brother)

Nathan Hesse as Bill (Nurse)

Max Barrow as Cousin Nate

Sunny Mabrey as Bonnie (Mamaw, 30's)

Brett Lorenzini as Jim (Papaw, 30's)

Tierney Smith as Young Bev (6 years)

Helen LeRoy as Cheryl

Kinsley Isla Dillon as Emma

Ryan Homchick as Adult Frank McFee

Joshua Stenvick as Chip

Bill Winkler as Brooks Houghton

Chase Anderson as Brett

Amy Parrish as Pamela

Ed Amatrudo as Rich

David de Vries as Hiram Walcott

Holly A. Morris as Cocktailer #1

Brandon Hirsch as Cocktailer #2

David Alexander as Server

Alexander Baxter as Obsequious Server

Steven Reddington as Waiter

Angelo Reyes as Wiry Law Partner

John Rymer as Stodgy Partner

Abigail Rose Cornell as Young Bonnie (Mamaw 13 Years)

Lowrey Brown as Adult Louis Zablocki

Hunter James Evers as Young J.D. (4 years)

Riley McNerney as Dane

Zele Avradopoulos as Pool Woman

David Jensen as Mr. Selby

Skylar Denney as Holler Aunt

John Whitley as Young Louis

Zac Pullam as Doug

Shane Donovan Lewis as Young Frank

Mike Senior as Officer #1

William Mark McCullough as Officer #2

Dylan Gage as Kameron

Hannah Pniewski as Katrina

David Silverman as Doctor

Jason Davis as Dr. Newton

Joshua Brady as Davis

Cory Chapman as Nasty Cashier

Tatom Pender as Nurse

Cathy Hope as Patient

David Atkinson as Ray

Adam Murray as Salesperson

Dianna Craig as Scared Woman

Emery Mae Edgeman as Meghan

Rohan Myers as Young Jim (Papaw 16 Years)

Matthew Alan Brady as Meals On Wheels Delivery Man

Lucy Capri as Young Lori (6 years)

Déjá Dee as Sally Coates

Daniel R. Hill as Kyle

Jordan Trovillion as Arguing Girlfriend

Yossie Mulyadi as Secretary at Club

Alisa Harris as ICU Nurse #1

Tiger Dawn as ICU Nurse #2

Darla Robinson as Rehab Mother

Belinda Keller as Rehab Recepcionist

Jessie Faye Shirley as Old Mamaw Blanton

Cheryl Howard as Nurse Vivian

Tim Abou-Nasr as Law Candidate Tim

Leland Thomas Griffin as Curt

Drew Emerson Jones as Officer Connor

Justin P. Turner as EMT #1

Joshua T. Schneider as EMT #2

Tony Ward as Marine Barber

Mara Hall as Dining Hall Manager

Tess Malis Kincaid as Jill at Financial Aid Office

Chris Charm as Gas Station Attendant

Mary Kraft as Intake Receptionist

Suehyla El-Attar Young as Shoe Store Manager

Matthew Withers as Study Hall Friend #1

Jessica Miesel as Study Hall Friend #2

Benjamin Rapsas as Study Hall Friend #3

Ethan Levy as Peter (uncredited)

Bret Aaron Knower as Middletown Resident (uncredited)

John E. Brownlee as Neighbor (uncredited)

Jenny McManus as Middletown Resident (uncredited)