John Goodman as Babe Ruth

Kelly McGillis as Claire Ruth

Trini Alvarado as Helen Ruth

Randy Steinmeyer as Ty Cobb

James Cromwell as Brother Mathias

Michael McGrady as Lou Gehrig

Richard Tyson as Guy Bush

Joseph Ragno as Miller Huggins

Ralph Marrero as Frank 'Ping' Bodie

Bernard Kates as Colonel Jack Ruppert

Stevie Lee as Eddie the Bat Boy

Bruce Boxleitner as Jumpin' Joe Dugan

Peter Donat as Frazee

J.C. Quinn as Jack Dunn

Robert Swan as George Ruth Sr.

Stephen Caffrey as Johnny Sylvester (at 30)

Danny Goldring as Bill Carrigan

Bernie Gigliotti as Al Capone

Michael Nicolosi as Jimmy Colosimmo

W. Earl Brown as Herb Pennock

Shannon Cochran as Flapper

Michael Papajohn as Heckler

Gene Weygandt as Mr. Sylvester

Brendan Hutt as Boy at St. Mary's

Jeffrey Wiseman as Boy at St. Mary's

Elizabeth Greenberg as Dorothy Ruth

Larry Cedar as Forbes Field Announcer

Alan Johnson as Orphanage Reporter

Michael Krawic as Theatre-Goer

Johanna McKay as Yankee Wife

Jim Ortlieb as Scribe

Scott Haven as Scribe

Tricia Munford as Ida Dugan, Jump's Wife

Matt Doherty as Boy in Car

Kara Zediker as Redhead