Pedro Pascal as Reed Richards / Mister Fantastic

Vanessa Kirby as Sue Storm / Invisible Woman

Ebon Moss-Bachrach as Ben Grimm / The Thing

Joseph Quinn as Johnny Storm / Human Torch

Ralph Ineson as Galactus

Julia Garner as Shalla-Bal / Silver Surfer

Paul Walter Hauser as Harvey Elder / Mole Man

Natasha Lyonne as Rachel Rozman

Sarah Niles as Lynne Nichols / F4 Chief of Staff

Mark Gatiss as Ted Gilbert

Ada Scott as Franklin Richards

Matthew Wood as H.E.R.B.I.E. (voice)

Angela Jones as Mole Man Attack Witness

Maisie Shakman as Donna / Saved Girl

Jay Underwood as Power Plant Worker #1

Michael Bailey Smith as Power Plant Worker #2

Alex Hyde-White as ABC Newscaster William Russell

Rebecca Staab as Channel 9 Newscaster Carolyn Haynes

Patrick Miller as Larry the Lobbyist

Mather Zickel as Boston Newscaster

Firdous Bamji as Yancy Street Man

Bertie Caplan as Wiseass Kid

Max Lester as Yancy Street Kid

Hunter del Valle Marfo as Yancy Street Kid

Riotafari Gardner as Yancy Street Kid

Isla McRae as Yancy Street Kid

Martin Wilkinson as Timely Employee #1

Greg Haiste as Timely Employee #2

Nathaniel Brimmer-Beller as WHIH Reporter Albert Taft

Mark Weinman as Baxter Reporter #1

Lizzie Clarke as Baxter Reporter #2

Richard Summers-Calvert as Baxter Reporter #3

Macaulay Cooper as Hooligan

Ankur Bahl as Pundit

Edward Bennett as Pundit

Krysten Peck as Sue Speech Crowd

Fintan Shevlin as Sue Speech Crowd

Louis Sparks as Sue Speech Crowd

Dana Myzer as Sue Speech Crowd

Iverson Yabut as Sue Speech Crowd

Russ Whismore as Sue Speech Crowd

Patricia García Rodríguez as Interpreter

Dede Ma as Interpreter

Kasra Farahani as Interpreter

Ortis Deley as Lagos Family

Florence Odumosu as Lagos Family

Ihla Omohegbe as Lagos Family

Aamaya Oyedele as Lagos Family

Isaiah Oyedele as Lagos Family

Joseph Davidson as New York Family

Cecilia Blair as New York Family

Dale Mathurin as New York Apartment Father

Iliana Norris as Shalla-Bal's Daughter

Vienna Norris as Shalla-Bal's Daughter

Ecow Smith-Asante as Ghanian Anchor

Simon Thorp as Australian Anchor

Kiff VandenHeuvel as Newscaster

Corey Burton as Ted Gilbert Announcer (voice)

Cheyenne Dasri as Sally the Makeup Artist

Eric Stroud as Stagehand

John Schwab as The Thing Acting Double

Jack Parker as H.E.R.B.I.E. Puppeteer

Sarah Mardel as H.E.R.B.I.E. Puppeteer

Arina Ii as H.E.R.B.I.E. Puppeteer

Alex J Sturman as Ted Gilbert Show Dancer

Grace Durkin as Ted Gilbert Show Dancer

Nahum McLean as Ted Gilbert Show Dancer

Redmand Rance as Ted Gilbert Show Dancer

Savannah Ffrench as Ted Gilbert Show Dancer

Robert Downey Jr. as Victor von Doom / Doctor Doom (uncredited)