Matilda Lawler as Flora

Alyson Hannigan as Phyllis

Ben Schwartz as George

Benjamin Evan Ainsworth as William

Danny Pudi as Miller

Darien Martin as Incandesto

Anna Deavere Smith as Dr. Meescham

Bobby Moynihan as Stanlee

John Kassir as Ulysses (voice)

Nancy Robertson as Tootie

Janeane Garofalo as Marissa

Kate Micucci as Rita

Christine Lee as Journalist

Jesse Reid as Chad

Javier Lacroix as Donald

David Milchard as Cook

Kyle Strauts as Shobo

Tori Katongo as The Mighty Condor

Emma Oliver as Flora 6 Yrs Old

Arkie Kandola as Binders Keepers Employee

Arran Henn as Reporter at Diner

Henry Mah as Binders Keepers Regional Manager

Malaika Jackson as Animal Control Tech

Shawn Robidoux as Animal Control Tech

Kate DiCamillo as Kate

Carolyn Yonge as Technician

Simon Chin as Police Officer

Rhona Rees as Police Officer

Craig Haas as Meter Man

Alex Kliner as Old Man

Tracy Chow as Comic Book Patron