Leonardo Pieraccioni as Doc

Harvey Keitel as Johnny Lowen

David Bowie as Jack Sikora

Sandrine Holt as Pearl

Alessia Marcuzzi as Mary

Jim van der Woude as Joshua

Yudii Mercredi as Jeremiah

Andrew Dunford as Piano player

Kwame Kwei-Armah as Rastafarian

Stephen Jenn as Albino

Michelle Gomez as Leather girl

Sean Baker as Telegraph operator

Donald Hodson as Mayor

Rosalind Knight as Miss Willow

Jimmy Herman as Indian grandfather

Wilma Pelly as Indian grandmother

Stephen Joseph Scott as Lieutenant

Valentina Carnelutti as 1st Dancing girl

Cristina Moglia as 2nd Dancing girl

Clive Kneller as Slim

Chris John Hartz as Old Grizzly

James Weedon as Truman

Giustina Morganti as Slim's wife

John Satriano as Mayor's son

Jean Heywood as Miss Comet

Nicholas Hunt as Hunter

Danilo Mattei as 1st Cardplayer

Bruce Byron as 2nd Cardplayer

Ante Novakovic as Town Drunk (uncredited)

Raul Bolanos as (uncredited)

Gerald Auger as Indian (uncredited)

Giovanni as Indian Man (uncredited)

Travis Dugas as Hawk (uncredited)

Jimmy Gardner as Sam Comet (uncredited)

Jessica James as (uncredited)