Joaquin Phoenix as Johnny

Gaby Hoffmann as Viv

Woody Norman as Jesse

Scoot McNairy as Paul

Molly Webster as Roxanne

Jaboukie Young-White as Fern

Deborah Strang as Carol

Sunni Patterson as Sunni

Jenny Eliscu as Waitress

Mary Passeri as Behavioral Center Nurse

Brandon Rush as ER Nurse

Brey'on Shaw as Brey'on / New Orleans Interviewee

Todd D'Amour as Parade Bystander 1

Beth Bartley as Parade Bystander 2

Artrial Clark as Parade Bystander 3

Eleanor Halm Simmons as Parade Bystander 4

Keisuke Hoashi as Dr. Hora

Maximilla Lukacs as Viv's Friend 1

Nancy Gell as Viv's Friend 2

Gita Reddy as Dr. Rao

Mya Gonzales as Detroit Kid 1

Cooper Jack Rubin as Detroit Kid 2

Faith Steptore as NOLA School Teacher

Mahfuzul Islam as Pharmacy Employee

Na'kyah Adjuman as Detroit Interviewee

Jayce Garrett as Detroit Interviewee

Adilem Hernandez as Detroit Interviewee

Joye Pyronneau as Detroit Interviewee

Malik Pyronneau as Detroit Interviewee

Tallulah Smith as Detroit Interviewee

Tobias Cen as New York Interviewee

Ambar Perez as New York Interviewee

Dora Dulge as New York Interviewee

Roselin Garcia as New York Interviewee

Louie Nathan as New York Interviewee

Evan Ortiz as New York Interviewee

Sophie Suzuki Shih as New York Interviewee

Tamar Tanis as New York Interviewee

Elvies Yuan as New York Interviewee

Devante Bryant as New Orleans Interviewee

Ethan Clubb as New Orleans Interviewee

Robin Hand as New Orleans Interviewee

London Hicks as New Orleans Interviewee

Rayne King as New Orleans Interviewee

May Maczka as New Orleans Interviewee

Steven Stewart as New Orleans Interviewee

Chrisette Thompson as New Orleans Interviewee

Leslie Feist as Wah Vocals (voice)

Elaine Kagan as Sarah Klein (uncredited)

Kate Adams as Viv's Friend (uncredited)

Joseph Bishop as Dancing Guy (uncredited)

Callan Farris as Detroit Kid (uncredited)

Khadija Emma Neumann as Detroit Kid (uncredited)