Anthony Ramos as Noah Diaz

Dominique Fishback as Elena Wallace

Peter Cullen as Optimus Prime (voice)

Ron Perlman as Optimus Primal (voice)

Peter Dinklage as Scourge (voice)

Michelle Yeoh as Airazor (voice)

Pete Davidson as Mirage (voice)

Liza Koshy as Arcee (voice)

Cristo Fernández as Wheeljack (voice)

Luna Lauren Velez as Breanna Diaz

Dean Scott Vazquez as Kris Diaz

Tobe Nwigwe as Reek

Sarah Stiles as Jillian

Leni Parker as Ms. Greene

Frank Marrs as Receptionist

Aidan Devine as Bishop

Kerwin Jackson as Hotel Security Guard

Mike Chute as NYC Police Officer

Tyler Hall as NYC Police Officer

Sean Tucker as Bridge Security Guard

Jay Farrar as Museum Guard

Lucas Huarancca as Amaru

Amiel Cayo as Amaru's Son

Santusa Cutipa as Amaru's Wife

Yesenia Inquillay as Amaru's Granddaughter

Sumac T'Ika as Amaru's Granddaughter

Josue Sallo as Amaru's Grandson

Mellissa Alvarez as Amaru's Daughter-In-Law

Gloria Cusi as Amaru's Relative

Michael Kelly as Agent Burke

Jason D. Avalos as Security Guard

Lesley Stahl as Lesley Stahl

John DiMaggio as Transit / Stratosphere (voice)

David Sobolov as Rhinox / Battletrap / Apelinq (voice)

Michaela Jaé Rodriguez as Nightbird (voice)

Colman Domingo as Unicron (voice)

Tongayi Chirisa as Cheetor (voice)

Luke Jones as Additional Voice (voice)

Domenic Di Rosa as Bus Driver

Seth Fuentes as Pedestrian

Jimmy Caspeur Leblanc as Buisnessman