Ryan Reynolds as Adam Reed

Walker Scobell as Young Adam

Mark Ruffalo as Louis Reed

Jennifer Garner as Ellie Reed

Zoe Saldaña as Laura

Catherine Keener as Maya Sorian

Alex Mallari Jr. as Christos

Braxton Bjerken as Ray Dollarhyde

Kasra Wong as Chuck

Lucie Guest as Young Sorian Body Double

Donald Sales as Paul the Bartender

Esther Ming Li as Sophie

Benjamin Wilkinson as Derek

Milo Shandel as Professor

Isaiah Haegert as 8-year-old Adam